Caspase-4 Directly Activates Caspase-9 in Endoplasmic Reticulum Stress-Induced Apoptosis in SH-SY5Y Cells

• Hoofdauteurs: Akiko Yamamuro (Auteur), Takashi Kishino (Auteur), Yu Ohshima (Auteur), Yasuhiro Yoshioka (Auteur), Tomoki Kimura (Auteur), Atsushi Kasai (Auteur), Sadaaki Maeda (Auteur)
• Formaat: Boek
• Gepubliceerd in: Elsevier, 2011-01-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

The present study investigated the function of caspase-4 in endoplasmic reticulum (ER) stress-induced apoptosis in human neuronal cell line SH-SY5Y. Tunicamycin, which is known to induce ER stress, activated both caspase-9 and caspase-4, and the activation of caspase-4 preceded that of caspase-9. Th...