Unnatural amino acid substitutions to improve in vivo stability and tumor uptake of 68Ga-labeled GRPR-targeted TacBOMB2 derivatives for cancer imaging with positron emission tomography

• Main Authors: Lei Wang (Author), Hsiou-Ting Kuo (Author), Zhengxing Zhang (Author), Chengcheng Zhang (Author), Chao-Cheng Chen (Author), Devon Chapple (Author), Ryan Wilson (Author), Nadine Colpo (Author), François Bénard (Author), Kuo-Shyan Lin (Author)
• Format: Book
• Published: SpringerOpen, 2024-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Overexpressed in various solid tumors, gastrin-releasing peptide receptor (GRPR) is a promising cancer imaging marker and therapeutic target. Although antagonists are preferable for the development of GRPR-targeted radiopharmaceuticals due to potentially fewer side effects, inter...