Unnatural amino acid substitutions to improve in vivo stability and tumor uptake of 68Ga-labeled GRPR-targeted TacBOMB2 derivatives for cancer imaging with positron emission tomography

• প্রধান লেখক: Lei Wang (লেখক), Hsiou-Ting Kuo (লেখক), Zhengxing Zhang (লেখক), Chengcheng Zhang (লেখক), Chao-Cheng Chen (লেখক), Devon Chapple (লেখক), Ryan Wilson (লেখক), Nadine Colpo (লেখক), François Bénard (লেখক), Kuo-Shyan Lin (লেখক)
• বিন্যাস: গ্রন্থ
• প্রকাশিত: SpringerOpen, 2024-02-01T00:00:00Z.
• বিষয়গুলি: article
• অনলাইন ব্যবহার করুন: Connect to this object online.

Abstract Background Overexpressed in various solid tumors, gastrin-releasing peptide receptor (GRPR) is a promising cancer imaging marker and therapeutic target. Although antagonists are preferable for the development of GRPR-targeted radiopharmaceuticals due to potentially fewer side effects, inter...