Combination Therapy of Navitoclax with Chemotherapeutic Agents in Solid Tumors and Blood Cancer: A Review of Current Evidence

• Main Authors: Nur Syahidah Nor Hisam (Author), Azizah Ugusman (Author), Nor Fadilah Rajab (Author), Mohd Faizal Ahmad (Author), Michael Fenech (Author), Sze Ling Liew (Author), Nur Najmi Mohamad Anuar (Author)
• Format: Book
• Published: MDPI AG, 2021-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Combination therapy emerges as a fundamental scheme in cancer. Many targeted therapeutic agents are developed to be used with chemotherapy or radiation therapy to enhance drug efficacy and reduce toxicity effects. ABT-263, known as navitoclax, mimics the BH3-only proteins of the BCL-2 family and has...