Synergistic effects of peripheral GABA and GABA-transaminase inhibitory drugs on food intake control and weight loss in high-fat diet-induced obese mice

• Egile Nagusiak: Tomoka Nagao (Egilea), Jason D. Braga (Egilea), Siyi Chen (Egilea), Masubon Thongngam (Egilea), Maesaya Chartkul (Egilea), Noriyuki Yanaka (Egilea), Thanutchaporn Kumrungsee (Egilea)
• Formatua: Liburua
• Argitaratua: Frontiers Media S.A., 2024-10-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

BackgroundDeveloping anti-obesity interventions targeting appetite or food intake, the primary driver of obesity, remains challenging. Here, we demonstrated that dietary γ-aminobutyric acid (GABA) with GABA-degradation inhibitory drugs could be an anti-obesity intervention possessing strong food int...