Synergistic effects of peripheral GABA and GABA-transaminase inhibitory drugs on food intake control and weight loss in high-fat diet-induced obese mice

• Main Authors: Tomoka Nagao (Author), Jason D. Braga (Author), Siyi Chen (Author), Masubon Thongngam (Author), Maesaya Chartkul (Author), Noriyuki Yanaka (Author), Thanutchaporn Kumrungsee (Author)
• Format: Book
• Published: Frontiers Media S.A., 2024-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BackgroundDeveloping anti-obesity interventions targeting appetite or food intake, the primary driver of obesity, remains challenging. Here, we demonstrated that dietary γ-aminobutyric acid (GABA) with GABA-degradation inhibitory drugs could be an anti-obesity intervention possessing strong food int...