Sodium valproate increases the brain isoform of glycogen phosphorylase: looking for a compensation mechanism in McArdle disease using a mouse primary skeletal-muscle culture in vitro

• Main Authors: Noemí de Luna (Author), Astrid Brull (Author), Josep Maria Guiu (Author), Alejandro Lucia (Author), Miguel Angel Martin (Author), Joaquin Arenas (Author), Ramon Martí (Author), Antoni L. Andreu (Author), Tomàs Pinós (Author)
• Format: Book
• Published: The Company of Biologists, 2015-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

McArdle disease, also termed 'glycogen storage disease type V', is a disorder of skeletal muscle carbohydrate metabolism caused by inherited deficiency of the muscle-specific isoform of glycogen phosphorylase (GP-MM). It is an autosomic recessive disorder that is caused by mutations in the...