Synthesis and in vitro and in vivo anti-inflammatory activity of novel 4-ferrocenylchroman-2-one derivatives

• Main Authors: Wei-Yun Guo (Author), Liu-Zeng Chen (Author), Bang-Nian Shen (Author), Xin-Hua Liu (Author), Guang-Ping Tai (Author), Qing-Shan Li (Author), Li Gao (Author), Ban-Feng Ruan (Author)
• Format: Book
• Published: Taylor & Francis Group, 2019-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

A series of novel 4-ferrocenylchroman-2-one derivatives were designed and synthesised to discover potent anti-inflammatory agents for treatment of arthritis. All the target compounds had been screened for their anti-inflammatory activity by evaluating the inhibition effect of LPS-induced NO producti...