Application of biomimetic HPLC to estimate lipophilicity, protein and phospholipid binding of potential peptide therapeutics

• मुख्य लेखकों: Klara Livia Valko (लेखक), Gabriela Ivanova-Berndt (लेखक), Paul Beswick (लेखक), Mark Kindey (लेखक), Dorothy Ko (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: International Association of Physical Chemists (IAPC), 2018-06-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Peptide therapeutics are new modalities offering several challenges to drug discovery. They are generally less stable and permeable in vivo. The characterization of their lipophilicity cannot be carried out using the traditional in silico or wet octanol/water partition coefficients. The prediction o...