Application of biomimetic HPLC to estimate lipophilicity, protein and phospholipid binding of potential peptide therapeutics

• Asıl Yazarlar: Klara Livia Valko (Yazar), Gabriela Ivanova-Berndt (Yazar), Paul Beswick (Yazar), Mark Kindey (Yazar), Dorothy Ko (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: International Association of Physical Chemists (IAPC), 2018-06-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

Peptide therapeutics are new modalities offering several challenges to drug discovery. They are generally less stable and permeable in vivo. The characterization of their lipophilicity cannot be carried out using the traditional in silico or wet octanol/water partition coefficients. The prediction o...