A major role of insulin in promoting obesity-associated adipose tissue inflammation

• Main Authors: David J. Pedersen (Author), Adilson Guilherme (Author), Laura V. Danai (Author), Lauren Heyda (Author), Anouch Matevossian (Author), Jessica Cohen (Author), Sarah M. Nicoloro (Author), Juerg Straubhaar (Author), Hye Lim Noh (Author), DaeYoung Jung (Author), Jason K. Kim (Author), Michael P. Czech (Author)
• Format: Book
• Published: Elsevier, 2015-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Adipose tissue (AT) inflammation is associated with systemic insulin resistance and hyperinsulinemia in obese rodents and humans. A longstanding concept is that hyperinsulinemia may promote systemic insulin resistance through downregulation of its receptor on target tissues. Here we teste...