A major role of insulin in promoting obesity-associated adipose tissue inflammation

• मुख्य लेखकों: David J. Pedersen (लेखक), Adilson Guilherme (लेखक), Laura V. Danai (लेखक), Lauren Heyda (लेखक), Anouch Matevossian (लेखक), Jessica Cohen (लेखक), Sarah M. Nicoloro (लेखक), Juerg Straubhaar (लेखक), Hye Lim Noh (लेखक), DaeYoung Jung (लेखक), Jason K. Kim (लेखक), Michael P. Czech (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Elsevier, 2015-07-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Objective: Adipose tissue (AT) inflammation is associated with systemic insulin resistance and hyperinsulinemia in obese rodents and humans. A longstanding concept is that hyperinsulinemia may promote systemic insulin resistance through downregulation of its receptor on target tissues. Here we teste...