Inhibitory effect of THPGV-0 on the histamine release from antigen-induced RBL-2H3 cells

• Auteurs principaux: Agung Endro Nugroho (Auteur), Ritmaleni Ritmaleni (Auteur), Novrizal Abdi Sahid (Auteur), Kazutaka Maeyama (Auteur)
• Format: Livre
• Publié: Universitas Gadjah Mada, 2010-10-01T00:00:00Z.
• Sujets: article
• Accès en ligne: Connect to this object online.

Tetrahydropentagamavunon-0 (THPGV-0) is assumed to be main metabolite product of biotransformation process of PGV-0. THPGV-0 was synthesized by converting PGV-0 to the compound by hydrogenation with Pd/C as a catalyst. PGV-0 potently inhibited the histamine release from rat mast cells in vitro and i...