Spatiotemporal analysis of mycolactone distribution in vivo reveals partial diffusion in the central nervous system.

• Autores principales: Emma Colucci-Guyon (Autor), Aline Rifflet (Autor), Sarah Saint-Auret (Autor), Anaëlle da Costa (Autor), Laurent Boucontet (Autor), Thomas Laval (Autor), Christophe Prehaud (Autor), Nicolas Blanchard (Autor), Jean-Pierre Levraud (Autor), Ivo G Boneca (Autor), Caroline Demangel (Autor), Laure Guenin-Macé (Autor)
• Formato: Libro
• Publicado: Public Library of Science (PLoS), 2020-12-01T00:00:00Z.
• Materias: article
• Acceso en línea: Connect to this object online.

Mycobacterium ulcerans, the causative agent of Buruli ulcer (BU) disease, is unique amongst human pathogens in its capacity to produce a lipid toxin called mycolactone. While previous studies have demonstrated that bacterially-released mycolactone diffuses beyond infection foci, the spatiotemporal d...