Spatiotemporal analysis of mycolactone distribution in vivo reveals partial diffusion in the central nervous system.

• Main Authors: Emma Colucci-Guyon (Author), Aline Rifflet (Author), Sarah Saint-Auret (Author), Anaëlle da Costa (Author), Laurent Boucontet (Author), Thomas Laval (Author), Christophe Prehaud (Author), Nicolas Blanchard (Author), Jean-Pierre Levraud (Author), Ivo G Boneca (Author), Caroline Demangel (Author), Laure Guenin-Macé (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2020-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Mycobacterium ulcerans, the causative agent of Buruli ulcer (BU) disease, is unique amongst human pathogens in its capacity to produce a lipid toxin called mycolactone. While previous studies have demonstrated that bacterially-released mycolactone diffuses beyond infection foci, the spatiotemporal d...