Britanin relieves ferroptosis-mediated myocardial ischaemia/reperfusion damage by upregulating GPX4 through activation of AMPK/GSK3β/Nrf2 signalling

• Hauptverfasser: Haoyang Lu (Verfasst von), Hui Xiao (Verfasst von), Manyu Dai (Verfasst von), Yangcheng Xue (Verfasst von), Ren Zhao (Verfasst von)
• Format: Buch
• Veröffentlicht: Taylor & Francis Group, 2022-01-01T00:00:00Z.
• Schlagworte: article
• Online-Zugang: Connect to this object online.

Context Ferroptosis was described as an important contributor to the myocardial ischaemia/reperfusion (MIR) injury, and britanin (Bri) was reported to exert antitumor and anti-inflammatory activities. Objective Our study explores the effect and mechanism of Bri on MIR damage. Materials and methods T...