Molecular properties, including chameleonicity, as essential tools for designing the next generation of oral beyond rule of five drugs

• Main Authors: Giulia Caron (Author), Diego Garcia Jimenez (Author), Maura Vallaro (Author), Luigi Vitagliano (Author), Lucia Lopez Lopez (Author), Giulia Apprato (Author), Giuseppe Ermondi (Author)
• Format: Book
• Published: International Association of Physical Chemists (IAPC), 2024-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background and Purpose. The classical drug discovery toolbox continually expands beyond traditional rule of five (Ro5)-compliant small molecules to include new chemical modalities for difficult-to-drug targets. The paper focuses on the molecular properties essential to drive oral bioavailability wit...