Molecular properties, including chameleonicity, as essential tools for designing the next generation of oral beyond rule of five drugs
Background and Purpose. The classical drug discovery toolbox continually expands beyond traditional rule of five (Ro5)-compliant small molecules to include new chemical modalities for difficult-to-drug targets. The paper focuses on the molecular properties essential to drive oral bioavailability wit...
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Formaat: | Boek |
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International Association of Physical Chemists (IAPC),
2024-08-01T00:00:00Z.
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A1234.567 |
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Kopie 1 | Beschikbaar |