Molecular properties, including chameleonicity, as essential tools for designing the next generation of oral beyond rule of five drugs

• Hoofdauteurs: Giulia Caron (Auteur), Diego Garcia Jimenez (Auteur), Maura Vallaro (Auteur), Luigi Vitagliano (Auteur), Lucia Lopez Lopez (Auteur), Giulia Apprato (Auteur), Giuseppe Ermondi (Auteur)
• Formaat: Boek
• Gepubliceerd in: International Association of Physical Chemists (IAPC), 2024-08-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

Background and Purpose. The classical drug discovery toolbox continually expands beyond traditional rule of five (Ro5)-compliant small molecules to include new chemical modalities for difficult-to-drug targets. The paper focuses on the molecular properties essential to drive oral bioavailability wit...