Molecular properties, including chameleonicity, as essential tools for designing the next generation of oral beyond rule of five drugs

• Autores principales: Giulia Caron (Autor), Diego Garcia Jimenez (Autor), Maura Vallaro (Autor), Luigi Vitagliano (Autor), Lucia Lopez Lopez (Autor), Giulia Apprato (Autor), Giuseppe Ermondi (Autor)
• Formato: Libro
• Publicado: International Association of Physical Chemists (IAPC), 2024-08-01T00:00:00Z.
• Materias: article
• Acceso en línea: Connect to this object online.

Background and Purpose. The classical drug discovery toolbox continually expands beyond traditional rule of five (Ro5)-compliant small molecules to include new chemical modalities for difficult-to-drug targets. The paper focuses on the molecular properties essential to drive oral bioavailability wit...