Molecular properties, including chameleonicity, as essential tools for designing the next generation of oral beyond rule of five drugs

• Váldodahkkit: Giulia Caron (Dahkki), Diego Garcia Jimenez (Dahkki), Maura Vallaro (Dahkki), Luigi Vitagliano (Dahkki), Lucia Lopez Lopez (Dahkki), Giulia Apprato (Dahkki), Giuseppe Ermondi (Dahkki)
• Materiálatiipa: Girji
• Almmustuhtton: International Association of Physical Chemists (IAPC), 2024-08-01T00:00:00Z.
• Fáttát: article
• Liŋkkat: Connect to this object online.

Background and Purpose. The classical drug discovery toolbox continually expands beyond traditional rule of five (Ro5)-compliant small molecules to include new chemical modalities for difficult-to-drug targets. The paper focuses on the molecular properties essential to drive oral bioavailability wit...