A randomized, controlled single, and multiple ascending dose trial of the safety, pharmacokinetics and pharmacodynamics of SN1011 in healthy subjects

• मुख्य लेखकों: Leilei Zhu (लेखक), Rong Shi (लेखक), Tongfang Zhao (लेखक), Yujie Ye (लेखक), Jie Tang (लेखक), Yihui Hu (लेखक), Peng Peng (लेखक), Dong Wang (लेखक), Clement Chong (लेखक), Guolin Xu (लेखक), Shui‐on Leung (लेखक), Wei'an Yuan (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Wiley, 2023-10-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Abstract The purpose of this study was to investigate the safety, tolerability, pharmacokinetics, and pharmacodynamics of SN1011, a novel Bruton tyrosine kinase (BTK) inhibitor, and food effects in healthy subjects. In this phase I trial, subjects received single ascending doses (SADs) of SN1011 (10...