A randomized, controlled single, and multiple ascending dose trial of the safety, pharmacokinetics and pharmacodynamics of SN1011 in healthy subjects

• Main Authors: Leilei Zhu (Author), Rong Shi (Author), Tongfang Zhao (Author), Yujie Ye (Author), Jie Tang (Author), Yihui Hu (Author), Peng Peng (Author), Dong Wang (Author), Clement Chong (Author), Guolin Xu (Author), Shui‐on Leung (Author), Wei'an Yuan (Author)
• Format: Book
• Published: Wiley, 2023-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract The purpose of this study was to investigate the safety, tolerability, pharmacokinetics, and pharmacodynamics of SN1011, a novel Bruton tyrosine kinase (BTK) inhibitor, and food effects in healthy subjects. In this phase I trial, subjects received single ascending doses (SADs) of SN1011 (10...