Preparation and evaluation of rotigotine-loaded implant for the treatment of Parkinson's disease and its evolution study

• المؤلفون الرئيسيون: Aiping Wang (مؤلف), Yanxiang Liu (مؤلف), Rongcai Liang (مؤلف), Xuemei Zhang (مؤلف), Kaoxiang Sun (مؤلف), Zimei Wu (مؤلف), Wanhui Liu (مؤلف)
• التنسيق: كتاب
• منشور في: Elsevier, 2016-05-01T00:00:00Z.
• الموضوعات: article
• الوصول للمادة أونلاين: Connect to this object online.

Purpose: To develop rotigotine-loaded implants (RI) to achieve continuous release of rotigotine for long duration for the treatment of Parkinson's disease (PD). Methods: RI was prepared by hot-melt extrusion method using poly (lactide-co-glycolide) (PLGA) as the matrix. In vitro drug release wa...