Preparation and evaluation of rotigotine-loaded implant for the treatment of Parkinson's disease and its evolution study

• Main Authors: Aiping Wang (Author), Yanxiang Liu (Author), Rongcai Liang (Author), Xuemei Zhang (Author), Kaoxiang Sun (Author), Zimei Wu (Author), Wanhui Liu (Author)
• Format: Book
• Published: Elsevier, 2016-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Purpose: To develop rotigotine-loaded implants (RI) to achieve continuous release of rotigotine for long duration for the treatment of Parkinson's disease (PD). Methods: RI was prepared by hot-melt extrusion method using poly (lactide-co-glycolide) (PLGA) as the matrix. In vitro drug release wa...