Preparation and evaluation of rotigotine-loaded implant for the treatment of Parkinson's disease and its evolution study

• Hlavní autoři: Aiping Wang (Autor), Yanxiang Liu (Autor), Rongcai Liang (Autor), Xuemei Zhang (Autor), Kaoxiang Sun (Autor), Zimei Wu (Autor), Wanhui Liu (Autor)
• Médium: Kniha
• Vydáno: Elsevier, 2016-05-01T00:00:00Z.
• Témata: article
• On-line přístup: Connect to this object online.

Purpose: To develop rotigotine-loaded implants (RI) to achieve continuous release of rotigotine for long duration for the treatment of Parkinson's disease (PD). Methods: RI was prepared by hot-melt extrusion method using poly (lactide-co-glycolide) (PLGA) as the matrix. In vitro drug release wa...