From drug response profiling to target addiction scoring in cancer cell models

• Главные авторы: Bhagwan Yadav (Автор), Peddinti Gopalacharyulu (Автор), Tea Pemovska (Автор), Suleiman A. Khan (Автор), Agnieszka Szwajda (Автор), Jing Tang (Автор), Krister Wennerberg (Автор), Tero Aittokallio (Автор)
• Формат: ‌
• Опубликовано: The Company of Biologists, 2015-10-01T00:00:00Z.
• Предметы: article
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Deconvoluting the molecular target signals behind observed drug response phenotypes is an important part of phenotype-based drug discovery and repurposing efforts. We demonstrate here how our network-based deconvolution approach, named target addiction score (TAS), provides insights into the functio...