From drug response profiling to target addiction scoring in cancer cell models

• Main Authors: Bhagwan Yadav (Author), Peddinti Gopalacharyulu (Author), Tea Pemovska (Author), Suleiman A. Khan (Author), Agnieszka Szwajda (Author), Jing Tang (Author), Krister Wennerberg (Author), Tero Aittokallio (Author)
• Format: Book
• Published: The Company of Biologists, 2015-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Deconvoluting the molecular target signals behind observed drug response phenotypes is an important part of phenotype-based drug discovery and repurposing efforts. We demonstrate here how our network-based deconvolution approach, named target addiction score (TAS), provides insights into the functio...