From drug response profiling to target addiction scoring in cancer cell models

• Główni autorzy: Bhagwan Yadav (Autor), Peddinti Gopalacharyulu (Autor), Tea Pemovska (Autor), Suleiman A. Khan (Autor), Agnieszka Szwajda (Autor), Jing Tang (Autor), Krister Wennerberg (Autor), Tero Aittokallio (Autor)
• Format: Książka
• Wydane: The Company of Biologists, 2015-10-01T00:00:00Z.
• Hasła przedmiotowe: article
• Dostęp online: Connect to this object online.

Deconvoluting the molecular target signals behind observed drug response phenotypes is an important part of phenotype-based drug discovery and repurposing efforts. We demonstrate here how our network-based deconvolution approach, named target addiction score (TAS), provides insights into the functio...