From drug response profiling to target addiction scoring in cancer cell models

• Váldodahkkit: Bhagwan Yadav (Dahkki), Peddinti Gopalacharyulu (Dahkki), Tea Pemovska (Dahkki), Suleiman A. Khan (Dahkki), Agnieszka Szwajda (Dahkki), Jing Tang (Dahkki), Krister Wennerberg (Dahkki), Tero Aittokallio (Dahkki)
• Materiálatiipa: Girji
• Almmustuhtton: The Company of Biologists, 2015-10-01T00:00:00Z.
• Fáttát: article
• Liŋkkat: Connect to this object online.

Deconvoluting the molecular target signals behind observed drug response phenotypes is an important part of phenotype-based drug discovery and repurposing efforts. We demonstrate here how our network-based deconvolution approach, named target addiction score (TAS), provides insights into the functio...