From drug response profiling to target addiction scoring in cancer cell models

• প্রধান লেখক: Bhagwan Yadav (লেখক), Peddinti Gopalacharyulu (লেখক), Tea Pemovska (লেখক), Suleiman A. Khan (লেখক), Agnieszka Szwajda (লেখক), Jing Tang (লেখক), Krister Wennerberg (লেখক), Tero Aittokallio (লেখক)
• বিন্যাস: গ্রন্থ
• প্রকাশিত: The Company of Biologists, 2015-10-01T00:00:00Z.
• বিষয়গুলি: article
• অনলাইন ব্যবহার করুন: Connect to this object online.

Deconvoluting the molecular target signals behind observed drug response phenotypes is an important part of phenotype-based drug discovery and repurposing efforts. We demonstrate here how our network-based deconvolution approach, named target addiction score (TAS), provides insights into the functio...