Mucoadhesive In Situ Rectal Gel Loaded with Rifampicin: Strategy to Improve Bioavailability and Alleviate Liver Toxicity

• Main Authors: Fakhria Al-Joufi (Author), Mohammed Elmowafy (Author), Nabil K. Alruwaili (Author), Khalid S. Alharbi (Author), Khaled Shalaby (Author), Shakir D. Alsharari (Author), Hazim M. Ali (Author)
• Format: Book
• Published: MDPI AG, 2021-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Although it is a front-line in tuberculosis treatment, rifampicin (RF) exhibits poor oral bioavailability and hepatotoxicity. Rectal mucoadhesive and in situ rectal gels were developed to overcome drug drawbacks. A RF/polyethylene glycol 6000 co-precipitate was first prepared in different ratios. Ba...