Mucoadhesive In Situ Rectal Gel Loaded with Rifampicin: Strategy to Improve Bioavailability and Alleviate Liver Toxicity

• मुख्य लेखकों: Fakhria Al-Joufi (लेखक), Mohammed Elmowafy (लेखक), Nabil K. Alruwaili (लेखक), Khalid S. Alharbi (लेखक), Khaled Shalaby (लेखक), Shakir D. Alsharari (लेखक), Hazim M. Ali (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: MDPI AG, 2021-03-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Although it is a front-line in tuberculosis treatment, rifampicin (RF) exhibits poor oral bioavailability and hepatotoxicity. Rectal mucoadhesive and in situ rectal gels were developed to overcome drug drawbacks. A RF/polyethylene glycol 6000 co-precipitate was first prepared in different ratios. Ba...