GYY4137, an H2S Slow-Releasing Donor, Prevents Nitrative Stress and α-Synuclein Nitration in an MPTP Mouse Model of Parkinson's Disease

• Autors principals: Xiaoou Hou (Autor), Yuqing Yuan (Autor), Yulan Sheng (Autor), Baoshi Yuan (Autor), Yali Wang (Autor), Jiyue Zheng (Autor), Chun-Feng Liu (Autor), Xiaohu Zhang (Autor), Li-Fang Hu (Autor)
• Format: Llibre
• Publicat: Frontiers Media S.A., 2017-10-01T00:00:00Z.
• Matèries: article
• Accés en línia: Connect to this object online.

The neuromodulator hydrogen sulfide (H2S) was shown to exert neuroprotection in different models of Parkinson's disease (PD) via its anti-inflammatory and anti-apoptotic properties. In this study, we evaluated the effect of an H2S slow-releasing compound GYY4137 (GYY) on a mouse PD model induce...