GYY4137, an H2S Slow-Releasing Donor, Prevents Nitrative Stress and α-Synuclein Nitration in an MPTP Mouse Model of Parkinson's Disease

• Main Authors: Xiaoou Hou (Author), Yuqing Yuan (Author), Yulan Sheng (Author), Baoshi Yuan (Author), Yali Wang (Author), Jiyue Zheng (Author), Chun-Feng Liu (Author), Xiaohu Zhang (Author), Li-Fang Hu (Author)
• Format: Book
• Published: Frontiers Media S.A., 2017-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The neuromodulator hydrogen sulfide (H2S) was shown to exert neuroprotection in different models of Parkinson's disease (PD) via its anti-inflammatory and anti-apoptotic properties. In this study, we evaluated the effect of an H2S slow-releasing compound GYY4137 (GYY) on a mouse PD model induce...