In vivo PET Imaging of [11C]CIMBI-5, a 5-HT2AR Agonist Radiotracer in Nonhuman Primates

• Autors principals: Jaya Prabhakaran (Autor), Christine DeLorenzo (Autor), Francesca Zanderigo (Autor), Gitte M Knudsen (Autor), Nic Gilling (Autor), Mali Pratap (Autor), Matthew J Jorgensen (Autor), James Daunais (Autor), Jay R Kaplan (Autor), Ramin V Parsey (Autor), J John Mann (Autor), Dileep Kumar (Autor)
• Format: Llibre
• Publicat: Frontiers Media S.A., 2019-07-01T00:00:00Z.
• Matèries: article
• Accés en línia: Connect to this object online.

Purpose: 5-HT2AR exists in high and low affinity states. Agonist PET tracers measure binding to the active high affinity site and thus provide a functionally relevant measure of the receptor. Limited in vivo data have been reported so far for a comparison of agonist versus antagonist tracers for 5-H...