In vivo PET Imaging of [11C]CIMBI-5, a 5-HT2AR Agonist Radiotracer in Nonhuman Primates

• Main Authors: Jaya Prabhakaran (Author), Christine DeLorenzo (Author), Francesca Zanderigo (Author), Gitte M Knudsen (Author), Nic Gilling (Author), Mali Pratap (Author), Matthew J Jorgensen (Author), James Daunais (Author), Jay R Kaplan (Author), Ramin V Parsey (Author), J John Mann (Author), Dileep Kumar (Author)
• Format: Book
• Published: Frontiers Media S.A., 2019-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Purpose: 5-HT2AR exists in high and low affinity states. Agonist PET tracers measure binding to the active high affinity site and thus provide a functionally relevant measure of the receptor. Limited in vivo data have been reported so far for a comparison of agonist versus antagonist tracers for 5-H...