Beneficial Metabolic Effects of Praliciguat, a Soluble Guanylate Cyclase Stimulator, in a Mouse Diet-Induced Obesity Model

• Principais autores: Chad D. Schwartzkopf (Autor), John R. Hadcock (Autor), Guang Liu (Autor), Peter Germano (Autor), Julien Roux (Autor), Courtney M. Shea (Autor), Emmanuel S. Buys (Autor), Juli E. Jones (Autor)
• Formato: Livro
• Publicado em: Frontiers Media S.A., 2022-03-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

Praliciguat is a soluble guanylate cyclase stimulator that elicits hemodynamic, anti-inflammatory, and antifibrotic effects in preclinical models of metabolic dysfunction. We assessed the metabolic effects of praliciguat in a mouse diet-induced obesity (DIO) model housed at thermoneutrality. At 6 we...