Beneficial Metabolic Effects of Praliciguat, a Soluble Guanylate Cyclase Stimulator, in a Mouse Diet-Induced Obesity Model

• Asıl Yazarlar: Chad D. Schwartzkopf (Yazar), John R. Hadcock (Yazar), Guang Liu (Yazar), Peter Germano (Yazar), Julien Roux (Yazar), Courtney M. Shea (Yazar), Emmanuel S. Buys (Yazar), Juli E. Jones (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: Frontiers Media S.A., 2022-03-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

Praliciguat is a soluble guanylate cyclase stimulator that elicits hemodynamic, anti-inflammatory, and antifibrotic effects in preclinical models of metabolic dysfunction. We assessed the metabolic effects of praliciguat in a mouse diet-induced obesity (DIO) model housed at thermoneutrality. At 6 we...