Beneficial Metabolic Effects of Praliciguat, a Soluble Guanylate Cyclase Stimulator, in a Mouse Diet-Induced Obesity Model

• প্রধান লেখক: Chad D. Schwartzkopf (লেখক), John R. Hadcock (লেখক), Guang Liu (লেখক), Peter Germano (লেখক), Julien Roux (লেখক), Courtney M. Shea (লেখক), Emmanuel S. Buys (লেখক), Juli E. Jones (লেখক)
• বিন্যাস: গ্রন্থ
• প্রকাশিত: Frontiers Media S.A., 2022-03-01T00:00:00Z.
• বিষয়গুলি: article
• অনলাইন ব্যবহার করুন: Connect to this object online.

Praliciguat is a soluble guanylate cyclase stimulator that elicits hemodynamic, anti-inflammatory, and antifibrotic effects in preclinical models of metabolic dysfunction. We assessed the metabolic effects of praliciguat in a mouse diet-induced obesity (DIO) model housed at thermoneutrality. At 6 we...