Curcumin analogues exert potent inhibition on human and rat gonadal 3β-hydroxysteroid dehydrogenases as potential therapeutic agents: structure-activity relationship and in silico docking

Curcuminoids are functional food additives, and the effect on gonadal hormone biosynthesis remains unclear. Gonads contain 3β-hydroxysteroid dehydrogenase isoforms, h3β-HSD2 (humans) and r3β-HSD1 (rats), which catalyse pregnenolone into progesterone. The potency and mechanisms of curcuminoids to inh...

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Main Authors: Xinyi Qiao (Author), Lei Ye (Author), Jialin Lu (Author), Chengshuang Pan (Author), Qianjin Fei (Author), Yang Zhu (Author), Huitao Li (Author), Han Lin (Author), Ren-shan Ge (Author), Yiyan Wang (Author)
Format: Book
Published: Taylor & Francis Group, 2023-12-01T00:00:00Z.
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