Curcumin analogues exert potent inhibition on human and rat gonadal 3β-hydroxysteroid dehydrogenases as potential therapeutic agents: structure-activity relationship and in silico docking

• Главные авторы: Xinyi Qiao (Автор), Lei Ye (Автор), Jialin Lu (Автор), Chengshuang Pan (Автор), Qianjin Fei (Автор), Yang Zhu (Автор), Huitao Li (Автор), Han Lin (Автор), Ren-shan Ge (Автор), Yiyan Wang (Автор)
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• Опубликовано: Taylor & Francis Group, 2023-12-01T00:00:00Z.
• Предметы: article
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Curcuminoids are functional food additives, and the effect on gonadal hormone biosynthesis remains unclear. Gonads contain 3β-hydroxysteroid dehydrogenase isoforms, h3β-HSD2 (humans) and r3β-HSD1 (rats), which catalyse pregnenolone into progesterone. The potency and mechanisms of curcuminoids to inh...