Potent carbonic anhydrase I, II, IX and XII inhibition activity of novel primary benzenesulfonamides incorporating bis-ureido moieties

• Main Authors: Tuba Tekeli (Author), Suleyman Akocak (Author), Andrea Petreni (Author), Nebih Lolak (Author), Servet Çete (Author), Claudiu T. Supuran (Author)
• Formato: Libro
• Publicado: Taylor & Francis Group, 2023-12-01T00:00:00Z.
• Subjects: article
• Acceso en liña: Connect to this object online.

A novel series of twelve aromatic bis-ureido-substituted benzenesulfonamides was synthesised by conjugation of aromatic aminobenzenesulfonamides with aromatic bis-isocyanates. The obtained bis-ureido-substituted derivatives were tested against four selected human carbonic anhydrase isoforms (hCA I,...