Potent carbonic anhydrase I, II, IX and XII inhibition activity of novel primary benzenesulfonamides incorporating bis-ureido moieties

• Главные авторы: Tuba Tekeli (Автор), Suleyman Akocak (Автор), Andrea Petreni (Автор), Nebih Lolak (Автор), Servet Çete (Автор), Claudiu T. Supuran (Автор)
• Формат: ‌
• Опубликовано: Taylor & Francis Group, 2023-12-01T00:00:00Z.
• Предметы: article
• Online-ссылка: Connect to this object online.

A novel series of twelve aromatic bis-ureido-substituted benzenesulfonamides was synthesised by conjugation of aromatic aminobenzenesulfonamides with aromatic bis-isocyanates. The obtained bis-ureido-substituted derivatives were tested against four selected human carbonic anhydrase isoforms (hCA I,...