Improved Computational Identification of Drug Response Using Optical Measurements of Human Stem Cell Derived Cardiomyocytes in Microphysiological Systems

• Autors principals: Karoline Horgmo Jæger (Autor), Verena Charwat (Autor), Bérénice Charrez (Autor), Henrik Finsberg (Autor), Mary M. Maleckar (Autor), Samuel Wall (Autor), Kevin E. Healy (Autor), Aslak Tveito (Autor)
• Format: Llibre
• Publicat: Frontiers Media S.A., 2020-02-01T00:00:00Z.
• Matèries: article
• Accés en línia: Connect to this object online.

Cardiomyocytes derived from human induced pluripotent stem cells (hiPSC-CMs) hold great potential for drug screening applications. However, their usefulness is limited by the relative immaturity of the cells' electrophysiological properties as compared to native cardiomyocytes in the adult huma...