Improved Computational Identification of Drug Response Using Optical Measurements of Human Stem Cell Derived Cardiomyocytes in Microphysiological Systems

• Main Authors: Karoline Horgmo Jæger (Author), Verena Charwat (Author), Bérénice Charrez (Author), Henrik Finsberg (Author), Mary M. Maleckar (Author), Samuel Wall (Author), Kevin E. Healy (Author), Aslak Tveito (Author)
• Format: Book
• Published: Frontiers Media S.A., 2020-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Cardiomyocytes derived from human induced pluripotent stem cells (hiPSC-CMs) hold great potential for drug screening applications. However, their usefulness is limited by the relative immaturity of the cells' electrophysiological properties as compared to native cardiomyocytes in the adult huma...