A Rho-kinase inhibitor reverses learning and memory deficits in a Rat model of chronic cerebral ischemia by altering Bcl-2/Bax-NMDAR signaling in the cerebral cortex

• Main Authors: Ming Ni (Author), Jigang Zhang (Author), Lin Huang (Author), Gaolin Liu (Author), Qin Li (Author)
• Format: Knjiga
• Izdano: Elsevier, 2018-10-01T00:00:00Z.
• Teme: article
• Online dostop: Connect to this object online.

The current study investigated whether a Rho-kinase inhibitor alleviated impairments in a rat model of chronic cerebral ischemia and examined the specific pathological mechanisms by which Rho-kinase impacts neuronal damage and cognitive dysfunction. Adult Sprague-Dawley rats underwent permanent bila...