Evidence for Non-Linear Pharmacokinetics of Oxytocin in Anesthetizetized Rat

• Main Authors: Eric Troncy (Author), Valérie Morin (Author), Jérôme R.E. del Castillo (Author), Simon Authier (Author), Norma Ybarra (Author), Colombe Otis (Author), Dominique Gauvin (Author), Jolanta Gutkowska (Author)
• Format: Book
• Published: Frontiers Media S.A., 2008-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Purpose: Because oxytocin (OT) is potentially useful in cardiovascular therapy but has hormonal roles on the cardiovascular and renal systems, we characterized its pharmacokinetic (PK) properties as a function of dose. Methods: A single intravenous bolus of OT was given at doses of 200, 300, 500, 10...