Evidence for Non-Linear Pharmacokinetics of Oxytocin in Anesthetizetized Rat

• Auteurs principaux: Eric Troncy (Auteur), Valérie Morin (Auteur), Jérôme R.E. del Castillo (Auteur), Simon Authier (Auteur), Norma Ybarra (Auteur), Colombe Otis (Auteur), Dominique Gauvin (Auteur), Jolanta Gutkowska (Auteur)
• Format: Livre
• Publié: Frontiers Media S.A., 2008-10-01T00:00:00Z.
• Sujets: article
• Accès en ligne: Connect to this object online.

Purpose: Because oxytocin (OT) is potentially useful in cardiovascular therapy but has hormonal roles on the cardiovascular and renal systems, we characterized its pharmacokinetic (PK) properties as a function of dose. Methods: A single intravenous bolus of OT was given at doses of 200, 300, 500, 10...