Leonurine-Repressed miR-18a-5p/SOCS5/JAK2/STAT3 Axis Activity Disrupts CML malignancy

• Main Authors: Hui-Min Liu (Author), Chun-Ling Guo (Author), Yao-Fang Zhang (Author), Jian-Fang Chen (Author), Zhi-Peng Liang (Author), Lin-Hua Yang (Author), Yan-Ping Ma (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Leonurine, an active natural alkaloid compound isolated from Herba leonuri, has been reported to exhibit promising anticancer activity in solid tumors. The aim of this study was to explore whether leonurine is able to inhibit chronic myeloid leukemia (CML) malignancy. Here, we found that leonurine d...