Glyburide reduces bacterial dissemination in a mouse model of melioidosis.

• Main Authors: Gavin C K W Koh (Author), Tassili A Weehuizen (Author), Katrin Breitbach (Author), Kathrin Krause (Author), Hanna K de Jong (Author), Liesbeth M Kager (Author), Arjan J Hoogendijk (Author), Antje Bast (Author), Sharon J Peacock (Author), Tom van der Poll (Author), Ivo Steinmetz (Author), W Joost Wiersinga (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2013-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Burkholderia pseudomallei infection (melioidosis) is an important cause of community-acquired Gram-negative sepsis in Northeast Thailand, where it is associated with a ~40% mortality rate despite antimicrobial chemotherapy. We showed in a previous cohort study that patients taking glyburide ( = glib...