The KIT ligand KITLG promotes portal vein tumor thrombosis by up-regulating COL4A1 through STAT3-SMAD2 signaling in hepatocellular carcinoma

• Main Authors: Feifei Mao (Author), Yuqiang Cheng (Author), Kang Wang (Author), Zongtao Chai (Author), Lei Guo (Author), Yanyan Xu (Author), Xue Chen (Author), Jie Shi (Author), Weixing Guo (Author), Junling Liu (Author), Shuqun Cheng (Author)
• Format: Book
• Published: Compuscript Ltd, 2024-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Portal vein tumor thrombosis (PVTT), a severe complication of hepatocellular carcinoma (HCC), markedly influences patient prognosis by fostering a hypercoagulable state. However, its molecular underpinnings remain largely unexplored. This study sheds light on the critical role of the KIT ligand (KIT...