Development of amorphous dispersions of artemether with hydrophilic polymers via spray drying: Physicochemical and in silico studies

• Main Authors: Jaywant N. Pawar (Author), Rahul T. Shete (Author), Avinash B. Gangurde (Author), Kailas K. Moravkar (Author), Sharadchandra D. Javeer (Author), Divakar R. Jaiswar (Author), Purnima D. Amin (Author)
• Format: Book
• Published: Elsevier, 2016-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Artemether (ARM) is a poorly water soluble and poorly permeable drug effective against acute and severe falciparum malaria, hence there is a strong need to improve its solubility. The objective of the study was to enhance the solubility and dissolution rate of ARM by preparation of solid dispersions...