Development of amorphous dispersions of artemether with hydrophilic polymers via spray drying: Physicochemical and in silico studies

• Główni autorzy: Jaywant N. Pawar (Autor), Rahul T. Shete (Autor), Avinash B. Gangurde (Autor), Kailas K. Moravkar (Autor), Sharadchandra D. Javeer (Autor), Divakar R. Jaiswar (Autor), Purnima D. Amin (Autor)
• Format: Książka
• Wydane: Elsevier, 2016-06-01T00:00:00Z.
• Hasła przedmiotowe: article
• Dostęp online: Connect to this object online.

Artemether (ARM) is a poorly water soluble and poorly permeable drug effective against acute and severe falciparum malaria, hence there is a strong need to improve its solubility. The objective of the study was to enhance the solubility and dissolution rate of ARM by preparation of solid dispersions...