Inhibition of tyrosinase activity and melanine pigmentation by 2-hydroxytyrosol

• Main Authors: Ryuji Uchida (Author), Seiko Ishikawa (Author), Hiroshi Tomoda (Author)
• Formato: Livro
• Publicado em: Elsevier, 2014-04-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

2-Hydroxytyrosol (2-HT), originally reported as a synthetic compound, was isolated for the first time as a fungal metabolite. 2-HT was found to inhibit mushroom tyrosinase with an IC50 value of 13.0 µmol/L. Furthermore, 2-HT dose-dependently inhibited tyrosinase activity (IC50, 32.5 µmol/L) in the c...