Prophylactic low-dose, bi-weekly benznidazole treatment fails to prevent Trypanosoma cruzi infection in dogs under intense transmission pressure.

• Main Authors: Juan M Bustamante (Author), Angel M Padilla (Author), Brooke White (Author), Lisa D Auckland (Author), Rachel E Busselman (Author), Stephanie Collins (Author), Elizabeth L Malcolm (Author), Briana F Wilson (Author), Ashley B Saunders (Author), Sarah A Hamer (Author), Rick L Tarleton (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2022-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Trypanosoma cruzi naturally infects a wide variety of wild and domesticated mammals, in addition to humans. Depending on the infection dose and other factors, the acute infection can be life-threatening, and in all cases, the risk of chagasic heart disease is high in persistently infected hosts. Dom...