A Standardized Chemically Modified Curcuma longa Extract Modulates IRAK-MAPK Signaling in Inflammation and Potentiates Cytotoxicity

• Main Authors: Minakshi Rana (Author), Preeti Maurya (Author), Sukka Santosh Reddy (Author), Vishal Singh (Author), Hafsa Ahmad (Author), Anil Kumar Dwivedi (Author), Madhu Dikshit (Author), Manoj Kumar Barthwal (Author)
• Format: Book
• Published: Frontiers Media S.A., 2016-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The TLR/IL-1R pathway is a critical signaling module that is misregulated in pathologies like inflammation and cancer. Extracts from turmeric (Curcuma longa L.) enriched in curcumin and carbonyls like turmerones have been shown to exert potent anti-inflammatory effects. The present study evaluated t...