Synthesis, anti-inflammatory, cytotoxic, and COX-1/2 inhibitory activities of cyclic imides bearing 3-benzenesulfonamide, oxime, and β-phenylalanine scaffolds: a molecular docking study

• Main Authors: Alaa A.-M (Author), Adel S. El-Azab (Author), Nawaf A. AlSaif (Author), Mohammed M. Alanazi (Author), Manal A. El-Gendy (Author), Ahmad J. Obaidullah (Author), Hamad M. Alkahtani (Author), Abdulrahman A. Almehizia (Author), Ibrahim A. Al-Suwaidan (Author)
• Format: Book
• Published: Taylor & Francis Group, 2020-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Cyclic imides containing 3-benzenesulfonamide, oxime, and β-phenylalanine derivatives were synthesised and evaluated to elucidate their in vivo anti-inflammatory and ulcerogenic activity and in vitro cytotoxic effects. Most active anti-inflammatory agents were subjected to in vitro COX-1/2 inhibitio...