Synthesis, anti-inflammatory, cytotoxic, and COX-1/2 inhibitory activities of cyclic imides bearing 3-benzenesulfonamide, oxime, and β-phenylalanine scaffolds: a molecular docking study

• Auteurs principaux: Alaa A.-M (Auteur), Adel S. El-Azab (Auteur), Nawaf A. AlSaif (Auteur), Mohammed M. Alanazi (Auteur), Manal A. El-Gendy (Auteur), Ahmad J. Obaidullah (Auteur), Hamad M. Alkahtani (Auteur), Abdulrahman A. Almehizia (Auteur), Ibrahim A. Al-Suwaidan (Auteur)
• Format: Livre
• Publié: Taylor & Francis Group, 2020-01-01T00:00:00Z.
• Sujets: article
• Accès en ligne: Connect to this object online.

Cyclic imides containing 3-benzenesulfonamide, oxime, and β-phenylalanine derivatives were synthesised and evaluated to elucidate their in vivo anti-inflammatory and ulcerogenic activity and in vitro cytotoxic effects. Most active anti-inflammatory agents were subjected to in vitro COX-1/2 inhibitio...